Growth disorders are conditions of abnormal growth in children. The disorders may be caused by poor nutrition, abnormal levels of certain hormones involved in growth, genetic disorders of bone growth, and other diseases.
KEYWORDS
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Endocrinology
Genetics
Human growth disorders
Human growth hormone
Puberty
Jeremy's Story
When Jeremy turned eight, he looked like he was trapped inside the body of a four-year-old. "My friends teased me and called me 'Shorty,'" he said. "I felt terrible being so much shorter than my brother who was three years younger."
His parents took him to see a pediatric endocrinologist * . The doctor took his medical history, blood tests, x-rays, and measurements. Jeremy's parents were told that his body was not making enough growth hormone. Daily shots of human growth hormone have helped Jeremy, and he is now taller than his brother.
What Is Normal Growth?
Everyone has a different size and shape, and there is a very wide range of what doctors consider "normal growth." In order to monitor growth, doctors use an established range of normal heights and weights for different age groups. From the time a child first goes to the doctor, measurements of height and weight are taken. The doctor uses a growth chart to compare a child's height and growth rate with those of others the same age. As a newborn, everyone starts out at about the same size. Yet, some end up short and some tall.
When developing a standard growth chart, researchers take a large number of children of different ages and make a graph of their heights and weights. The height at the 50th percentile means the height at which half of the children of that age are taller and half are shorter. The 25th percentile means that three quarters (75 percent) of the children are taller at that age, and one quarter (25 percent) are shorter. The 75th percentile means that three quarters of the children (75 percent) will be shorter and one quarter (25 percent) taller.
People vary greatly, and if children are between the 3rd and 97th percentile, and if they growing at a normal rate, they usually are regarded as normal. If children are outside these ranges (over 97th percentile or under 3rd percentile), the doctor may look for some explanation. Most often, these children simply have inherited "short" or "tall" genes from their parents, and they will continue to grow at a normal pace.
Growth and Puberty
At the time of adolescence, a growth spurt normally occurs. Generally, growth spurts for girls start about two years earlier than growth spurts for boys. Rates of growth and change during puberty vary with the individual. Parents' growth and puberty patterns often are passed on through their genes to their children: If one or both parents had a late puberty, then their children are more likely to reach puberty later and to experience a later growth spurt. The medical term for this "late bloomer" pattern is constitutional growth delay.
* endocrinologist (en-do-krin-OL-ojist) is a doctor who specializes in treating patients with hormone-related disorders.
Sex hormones
The increase in growth rate that occurs during puberty is driven by the body's increase in production of sex hormones: estrogen from the ovaries in girls, and testosterone from the testicles in boys. These hormones cause the skeleton to grow and to mature more rapidly. Hormones produced by the adrenal glands at puberty contribute to the development of pubic hair (near the genitals) and underarm hair, but have little effect on bone growth. It follows, then, that disorders of pubertal development can affect a child's growth pattern and ultimate height. Pubertal disorders usually are grouped into two categories: precocious or premature puberty (which starts earlier than expected), and delayed or late puberty.
Precocious puberty
In general, puberty is considered precocious (early) if changes in sexual development occur before age eight for girls and before age ten for boys. Most cases of precocious puberty result from the premature "switching on" of the puberty control center in the brain, located in the part of the brain called the hypothalamus (hy-po-THAL-a-mus). Hormones from the hypothalamus trigger the release of hormones from the pituitary gland (located at the base of the brain), which in turn stimulate the ovaries in girls and the testicles in boys to produce the higher levels of sex hormones needed to bring about the bodily changes of puberty.
Children with precocious puberty experience early growth spurts because of the abnormally early rise in sex hormone levels in their bodies. Although initially this causes these children to grow taller than others their age, their skeletons mature more rapidly, often causing them to stop growing at an early age. Therefore, if precocious puberty is left untreated, it may lead to a decrease in a child's ultimate height.
There are many possible causes for precocious puberty, including brain tumors and other disorders of the central nervous system; and tumors or other conditions that cause the gonads or adrenal glands to overproduce sex hormones. In girls, however, the majority of cases of precocious puberty are idiopathic (id-ee-o-PATH-ik), which means the precise cause is unknown.
Precocious puberty often can be treated effectively or controlled with medications that decrease the overproduction of sex hormones or that block their effects on the body. In many cases, this type of treatment can prevent or decrease the shortening of the child's ultimate height that would otherwise occur.
Delayed puberty
Delayed puberty occurs when the hormonal changes of puberty occur later than normal, or not at all. Puberty is considered late if it has not begun by age 13 in girls or by age 15 in boys. Most children who experience delayed puberty are following the normal pattern called constitutional growth delay discussed previously.
Several medical conditions (such as disorders of the hypothalamus, pituitary, ovaries, and testicles) can result in delayed puberty by interfering with the pubertal rise in sex hormones. Many chronic disorders of other body organs and systems (such as the intestines and lungs), as well as long-term treatments with certain medications (such as cortisone) also may cause delayed puberty.
As would be expected, children with delayed puberty do not experience growth spurts at the usual age, so they lag behind in height as their peers grow rapidly and mature sexually. When puberty finally occurs for these children, on its own or as a result of treatment, they "catch up": They may continue to grow into their late teens and may even exceed the final adult heights of some of their peers.
How Does Growth Take Place?
Growth occurs when bones of the arms, legs, and back increase in size. The long bones of the limbs have a growth plate at the end. The growth plate is made of cartilage, which is a tough, elastic tissue. Cartilage cells in the growth plate multiply and move down the bone to produce a matrix, or tissue from which new bone is formed. These cartilage cells then die, leaving spaces. Special cells called osteoblasts (OS-tee-o-blasts), meaning bone beginners, then produce bone (by laying down the minerals calcium and phosphorus) to fill the spaces and replace the matrix. Once all the cartilage in the growth plate has been turned to bone, growth stops. This usually occurs before ages 16 to 18. An x-ray of the hand or knee can show the doctor the bone age (maturity of the bone) and how much potential growth remains.
Why Do Some Children Not Grow Normally?
Nutrition
Children with poor nutrition may have poor growth. A balanced diet and adequate protein are essential for normal growth. Some parts of the world have serious problems with malnutrition, and the growth of children may be affected in these areas.
Chronic diseases
Chronic diseases that may impair growth include diabetes, congenital heart disorders, sickle cell disease, chronic kidney failure, cystic fibrosis, and rheumatoid arthritis.
Bone Disorders
One form of extreme short stature (height) is caused by abnormal formation and growth of cartilage and bone. Children with skeletal dysplasia * or chondrodystrophies * are short and have abnormal body proportions. Their intelligence levels usually are normal. Most of these conditions are inherited or occur due to genetic mutations (changes).
Intrauterine growth retardation (IUGR)
If growth in the uterus is interrupted while a fetus is forming or developing, the condition is called intrauterine (meaning within the uterus) growth retardation or IUGR. IUGR is not the same as when a baby is born prematurely. The small size of a premature infant usually is normal according to the gestational (jes-TAY-shun-al) age (or the age from conception).
* dysplasia (dis-PLAY-zha) means abnormal growth or development.
* chrondrodystrophy (kon-dro-DIS-trof-ee) means abnormal growth at the ends of the bones.
Failure to grow normally in the uterus may result from a problem with the placenta (the organ that supplies nutrients and oxygen to the baby). Growth of the fetus can be affected if the mother smokes cigarettes or drinks alcohol during the pregnancy. Infections, such as German measles, may cause the problem, and sometimes the cause cannot be determined.
Failure to thrive (FTT)
Failure to thrive (FTT), or inadequate weight gain anytime after birth, occurs frequently in infants. There are many possible causes, and the doctor must examine the child carefully. Often, the baby or child simply is not getting enough to eat. Sometimes there are other illnesses interfering with weight gain that must be treated.
Genetic conditions
Several genetic conditions may involve problems with growth. One such condition is Turner syndrome. Girls with Turner syndrome have only one X chromosome or a second X chromosome that may be abnormal or incomplete. Affected girls are short and have underdeveloped ovaries.
Marfan syndrome is a hereditary condition affecting connective tissue and is associated with tall stature. People with Marfan syndrome have very long arms and legs, eye problems, and differences in facial features. Other physical problems, such as heart abnormalities, also may be present. It is commonly believed that Abraham Lincoln had Marfan syndrome.
Hormones and Growth Disorders
Growth is controlled by hormones (chemical messengers) from various glands. One of the most important, growth hormone, is secreted by the pituitary gland. The gland looks like a peanut sitting at the base of the brain. Other hormones also are essential for growth. The thyroid gland in the neck secretes thyroxine, a hormone required for normal bone growth. Sex hormones from the ovaries (estrogen) and testicles (testosterone) are essential for the growth spurt and other body changes that occur at puberty.
Pituitary hormones
The pituitary gland is attached by a stalk to the hypothalamus, an area of the brain that controls the function of the pituitary. The anterior or front part of the pituitary gland secretes the following hormones that can affect growth:
Growth hormone to regulate bone growth
Thyroid-stimulating hormone to control the production and secretion of thyroid hormones
Gonad-stimulating hormones for development of the sex glands (gonads) and secretion of sex hormones
Adrenal-stimulating hormone to regulate the secretion of adrenal gland hormones.
Too little growth hormone (hypopituitarism)
Sometimes the pituitary gland does not make enough growth hormone. Usually, this will slow a child's growth rate to less than 2 inches a year. The deficiency may appear at any time during infancy or childhood. When doctors have ruled out other causes of growth failure, they may recommend special tests for growth hormone (GH) deficiency. Children with growth hormone deficiency are treated with daily injections of the hormone, often for a period of years. With early diagnosis and treatment, these children usually increase their rate of growth, and may catch up to achieve average or near-average height as adults.
In pituitary dwarfism, caused by low amounts of growth hormone, the person is short but has normal body proportions. This is different from other forms of dwarfism due to genetic skeletal dysplasias. In these cases, the person with dwarfism is short, and the growth of the arms, legs, torso, and head often is out of proportion. For example, the person's arms and legs may appear relatively smaller than the head or torso.
Too much growth hormone (hyperpituitarism)
Two conditions arise from excessive amounts of growth hormone in the body: acromegaly (ak-ro-MEG-a-lee) and gigantism. The cause usually is a benign * pituitary tumor.
Acromegaly, a condition caused by increased secretion of growth hormone after normal growth has been completed, occurs in adults. The condition is rare, occurring in 6 out of 100,000 people. Because the adult cannot grow taller, the excess growth hormone in acromegaly causes adult bones to thicken and other structures and organs to grow larger. Usually, it does not appear until middle age, when the person notes a tightening of a ring on the finger, or an increase in shoe size. Tests at that time may reveal a pituitary tumor.
* benign means not cancerous or spreading and contained in one area.
Gigantism occurs when excessive secretion of growth hormone occurs in children before normal growth has stopped. This results in the overgrowth of long bones. The vertical growth in height is accompanied by growth in muscle and organs. The result is a person who is very tall, with a large jaw, large face, large skull, and very large hands and feet. Many health problems may be associated with gigantism, including heart disease and vision problems. Delayed puberty also may occur in this condition. Surgery or radiation can correct the problem. Hormone replacement may be necessary if there is pituitary damage from this treatment.
Too little thyroid hormone (hypothyroidism)
The thyroid gland looks like a big butterfly at the base of the neck. One wing is on one side of the windpipe or trachea, and the other on the other side. The wings are joined by a thin strip of thyroid tissue. The thyroid gland makes the hormone thyroxine (thy-ROX-een).
The thyroid is controlled by the pituitary gland, which makes thyroid-stimulating hormone. The hormone thyroxine controls the rate of chemical reactions (or metabolism) in the body. Too much thyroxine, or hyperthyroidism, speeds up metabolism.
Hypothyroidism is the opposite. Hypothyroidism is caused by the body's underproduction of thyroid hormone, and this affects many different body processes.
A child with thyroid hormone deficiency has slow growth and is physically and mentally sluggish. The lack of this hormone may be present at birth, if the thyroid gland did not develop properly in the fetus. Or the problem may develop during childhood or later in life as a result of certain diseases of the thyroid.
In most states, babies are tested for hypothyroidism at birth. Blood tests can detect the problem, and treatment usually is a daily pill that replaces the missing thyroid hormone. Early diagnosis and continuing treatment help these children grow and develop normally.
Too much cortisol (Cushing's syndrome)
The adrenal glands, which are located on top of the kidneys in the abdomen, secrete the hormone cortisol. If too much cortisol is made by the child's adrenals, or if large doses of the hormone are given to the child to treat certain diseases, Cushing's syndrome may develop. Children with this syndrome grow slowly, gain weight excessively, and may experience delayed puberty due to the effects of the abnormally large amounts of cortisol in the body.
A Complex Problem
There are many causes for growth problems. In order to detect these disorders early, it is important for doctors to track growth carefully in infants and children. Many of these conditions can be treated effectively, resulting in more normal adult heights for children with growth disorders.
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